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Increased plasmid copy number is essential for Yersinia T3SS function and virulence
Umeå Centre for Microbial Research (UCMR), Department of Molecular Biology, Umeå University, Umeå, Sweden; Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umeå, Sweden. (Helen Wang)
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2016 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 353, no 6298, p. 492-495Article in journal (Refereed) Published
Abstract [en]

Pathogenic bacteria have evolved numerous virulence mechanisms that are essential for establishing infections. The enterobacterium Yersinia uses a type III secretion system (T3SS) encoded by a 70-kilobase, low-copy, IncFII-class virulence plasmid. We report a novel virulence strategy in Y. pseudotuberculosis in which this pathogen up-regulates the plasmid copy number during infection. We found that an increased dose of plasmid- encoded genes is indispensable for virulence and substantially elevates the expression and function of the T3SS. Remarkably, we observed direct, tight coupling between plasmid replication and T3SS function. This regulatory pathway provides a framework for further exploration of the environmental sensing mechanisms of pathogenic bacteria.

Place, publisher, year, edition, pages
2016. Vol. 353, no 6298, p. 492-495
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Microbiology in the medical area
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URN: urn:nbn:se:uu:diva-382895DOI: 10.1126/science.aaf7501ISI: 000380583600042PubMedID: 27365311OAI: oai:DiVA.org:uu-382895DiVA, id: diva2:1313720
Available from: 2019-05-06 Created: 2019-05-06 Last updated: 2019-05-09Bibliographically approved

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