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The Role of Mutation Bias in Adaptive Evolution
Lund Univ, Dept Biol, SE-22362 Lund, Sweden.ORCID iD: 0000-0001-9006-016X
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
2019 (English)In: Trends in Ecology & Evolution, ISSN 0169-5347, E-ISSN 1872-8383, Vol. 34, no 5, p. 422-434Article, review/survey (Refereed) Published
Abstract [en]

Mutational input is the ultimate source of genetic variation, but mutations are not thought to affect the direction of adaptive evolution. Recently, critics of standard evolutionary theory have questioned the random and non-directional nature of mutations, claiming that the mutational process can be adaptive in its own right. We discuss here mutation bias in adaptive evolution. We find little support for mutation bias as an independent force in adaptive evolution, although it can interact with selection under conditions of small population size and when standing genetic variation is limited, entirely consistent with standard evolutionary theory. We further emphasize that natural selection can shape the phenotypic effects of mutations, giving the false impression that directed mutations are driving adaptive evolution.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE LONDON , 2019. Vol. 34, no 5, p. 422-434
National Category
Evolutionary Biology Genetics
Identifiers
URN: urn:nbn:se:uu:diva-383045DOI: 10.1016/j.tree.2019.01.015ISI: 000464931300008PubMedID: 31003616OAI: oai:DiVA.org:uu-383045DiVA, id: diva2:1315364
Funder
Swedish Research Council, 2016-03356Swedish Research Council, 2015-05223Available from: 2019-05-13 Created: 2019-05-13 Last updated: 2019-05-13Bibliographically approved

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