uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
COPD patients with peripheral airway obstruction reversibility identified by exhaled nitric oxide
Univ Libre Bruxelles, Erasme Univ Hosp, Chest Dept, Brussels, Belgium.
Univ Libre Bruxelles, Erasme Univ Hosp, Chest Dept, Brussels, Belgium.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
Univ Libre Bruxelles, Erasme Univ Hosp, Chest Dept, Brussels, Belgium.
2019 (English)In: Journal of Breath Research, ISSN 1752-7155, E-ISSN 1752-7163, Vol. 13, no 3, article id 036002Article in journal (Refereed) Published
Abstract [en]

Rationale:

Besides its role as an inflammatory marker in asthma, fractional exhaled nitric oxide (FENO) provides information on the extent of the airway obstruction process through evaluating its change after bronchodilation.

Objective:

To investigate whether FENO change after bronchodilation can identify different sites of airway obstruction in COPD patients.

Methods:

FENO, FEV(1 )and the slopes (S) of the alveolar plateau of the single breath washout test (SBWT) were measured in 61 stable COPD patients (FEV1 34.5% predicted) before and after the inhalation of 400 mu g salbutamol. SBWT used Helium (He), and sulfur-hexafluoride (SF6). Obstruction relief occurring in pre-acinar and intra-acinar small airways is expected to decrease S-He and S-F6 , respectively. Indices changes (Delta) after bronchodilation were expressed as a percentage of pre-bronchodilation values.

Results:

FENO stability (vertical bar Delta FENO vertical bar <= 11%) was observed in 19 patients [-2.7(6.7)%] [mean (SD)] (NO = group); Delta FENO > 11% [+37.4(27.7)%] in 20 patients (NO+group) and Delta FENO < -11% in 22 patients [-31.2(9.8)%] (NO- group). A similar Delta FEV1 (p = 0.583; [+9.4(9.6)%]) was found in the three groups. In NO = and NO+ groups, neither S-He nor S-SF6 changed; in NO- both S-He [-12.4(27.5)%, p = 0.007] and S-SF6 [ -20.2(20.4)%, p < 0.001] significantly decreased.

Conclusion:

Different patterns of FENO response to beta(2) -agonists were observed in COPD most likely depending on the extent of the dilation process. A profile of airway obstruction with an extensive beta(2) -agonist response down to lung periphery is identified by FENO reduction after acute bronchodilation in 30% of COPD patients. The clinical relevance of this profile requires further investigation.

Place, publisher, year, edition, pages
2019. Vol. 13, no 3, article id 036002
Keywords [en]
FENO, bronchodilation, single breath washout test, beta(2)-agonist, SABA
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-382239DOI: 10.1088/1752-7163/ab0a14ISI: 000463138100002PubMedID: 30802891OAI: oai:DiVA.org:uu-382239DiVA, id: diva2:1316143
Available from: 2019-05-16 Created: 2019-05-16 Last updated: 2019-05-16Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Malinovschi, Andrei

Search in DiVA

By author/editor
Malinovschi, Andrei
By organisation
Clinical Physiology
In the same journal
Journal of Breath Research
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 21 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf