uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Mind the gaps: Clinical trial concepts to address unanswered questions in aeroallergen immunotherapy-An NIAID/AHRQ Workshop
NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD USA.
Johns Hopkins Univ, Baltimore, MD USA.
Stanford Univ, Stanford, CA 94305 USA.
Childrens Hosp Colorado, Aurora, CO USA;Univ Colorado, Sch Med, Aurora, CO USA.
Show others and affiliations
2019 (English)In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 143, no 5, p. 1711-1726Article in journal (Refereed) Published
Abstract [en]

The Agency for Healthcare Research and Quality and the National Institute of Allergy and Infectious Diseases organized a workshop to develop trial concepts that could improve the use and effectiveness of aeroallergen immunotherapy (AAIT). Expert groups were formed to accomplish the following tasks: (1) propose a study design to compare the effectiveness and safety of subcutaneous versus sublingual AAIT; (2) propose a study design to compare the effectiveness and safety of AAIT by using 1 or a few allergens versus all or most allergens to which a patient is sensitized; (3) propose a study design to determine whether AAIT can alter the progression of childhood allergic airways disease; and (4) propose a study design to determine the optimal dose and duration of AAIT to achieve maximal effectiveness with acceptable safety. Study designs were presented by the workgroups, extensively discussed at the workshop, and revised for this report. The proposed trials would be of long duration and require large highly characterized patient populations. Scientific caveats and feasibility matters are discussed. These concepts are intended to help the development of clinical trials that can address some of the major questions related to the practice of AAIT for the management and prevention of allergic airways disease.

Place, publisher, year, edition, pages
MOSBY-ELSEVIER , 2019. Vol. 143, no 5, p. 1711-1726
Keywords [en]
Aeroallergen, immunotherapy, asthma, allergic rhinitis, rhinoconjunctivitis, multi-allergen, prevention
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-383843DOI: 10.1016/j.jaci.2019.01.032ISI: 000466784600005PubMedID: 30731123OAI: oai:DiVA.org:uu-383843DiVA, id: diva2:1318135
Available from: 2019-05-27 Created: 2019-05-27 Last updated: 2019-05-27Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Dreborg, Sten

Search in DiVA

By author/editor
Dreborg, Sten
By organisation
Paediatric Inflammation Research
In the same journal
Journal of Allergy and Clinical Immunology
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 2 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf