uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Expression of GNAZ, encoding the G alpha(z) protein, predicts survival in mantle cell lymphoma
Broad Inst MIT & Harvard, Prote & Biomarkers, Cambridge, MA 02142 USA.
Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden.
Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
Show others and affiliations
2019 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 185, no 4, p. 708-712Article in journal (Refereed) Published
Abstract [en]

Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reaction data from 18 sorted primary MCL cells and 108 MCL biopsies compared to non-malignant tissue, reveals that GNAZ expression predicts poor clinical outcome of MCL patients (Cox regression, P = 0 center dot 014) and lymphocytosis (Mann-Whitney, P = 0 center dot 011). We show that GNAZ translates to G alpha(z) protein - a signalling molecule within the G-protein coupled receptor network. Our findings suggest that GNAZ/G alpha(z) contribute to the MCL pathobiology.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 185, no 4, p. 708-712
Keywords [en]
mantle cell lymphoma, G-protein coupled receptors, G-proteins, prognosis, lymphocytosis
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-383841DOI: 10.1111/bjh.15810ISI: 000467276100010PubMedID: 30788840OAI: oai:DiVA.org:uu-383841DiVA, id: diva2:1318138
Funder
Swedish Society for Medical Research (SSMF)Available from: 2019-05-27 Created: 2019-05-27 Last updated: 2019-05-27Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Sutton, Lesley AnnRosenquist, Richard

Search in DiVA

By author/editor
Sutton, Lesley AnnRosenquist, Richard
By organisation
Department of Immunology, Genetics and PathologyScience for Life Laboratory, SciLifeLab
In the same journal
British Journal of Haematology
Hematology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 9 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf