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Charting Angiosperm Chemistry: Evolutionary Perspective on Specialized Metabolites Reflected in Chemical Property Space
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.ORCID iD: 0000-0002-9991-8406
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.ORCID iD: 0000-0003-2043-4183
2019 (English)In: Journal of Natural Products, ISSN 0163-3864, E-ISSN 1520-6025, Vol. 82, no 4, p. 798-812Article in journal (Refereed) Published
Abstract [en]

Plants possess an outstanding chemical diversity of specialized metabolites developed to adapt to environmental niches and increase fitness. The observed diversity is hypothesized to result from various evolutionary mechanisms, such as the continuous branching off and extension of existing biosynthetic pathways or enhanced levels of catalytic promiscuity in certain enzymes. In this study, ChemGPS-NP has been employed to chart the distribution and diversity of physicochemical properties for selected types of specialized metabolites from the angiosperms. Utilizing these charts, it is analyzed how different properties of various types of specialized metabolites change in different plant groups, and the chemical diversity from the volume they occupy in chemical property space is evaluated. In this context, possible underlying evolutionary mechanisms are discussed, which could explain the observed distribution and behavior in chemical property space. Based on these studies, it is demonstrated that evolutionary processes in plant specialized metabolism and the resultant metabolic diversification are reflected in chemical property space.

Place, publisher, year, edition, pages
2019. Vol. 82, no 4, p. 798-812
National Category
Bioinformatics and Systems Biology Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-383876DOI: 10.1021/acs.jnatprod.8b00767ISI: 000466442100014PubMedID: 30912945OAI: oai:DiVA.org:uu-383876DiVA, id: diva2:1323545
Funder
EU, FP7, Seventh Framework Programme, 606895-MedPlantAvailable from: 2019-06-12 Created: 2019-06-12 Last updated: 2019-06-12Bibliographically approved

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Henz Ryen, AstridBacklund, Anders

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