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Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.ORCID iD: 0000-0001-9818-4052
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Kaohsiung Med Univ Hosp, Div Infect Dis, Dept Internal Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Sepsis Res Ctr, Sch Med,Grad Inst Med, Kaohsiung, Taiwan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Kaohsiung Med Univ Hosp, Div Infect Dis, Dept Internal Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Sepsis Res Ctr, Sch Med,Grad Inst Med, Kaohsiung, Taiwan;Natl Chiao Tung Univ, Coll Biol Sci & Technol, Dept Biol Sci & Technol, Hsinchu, Taiwan.
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2019 (English)In: Matrix Biology, ISSN 0945-053X, E-ISSN 1569-1802, Vol. 78-79, p. 100-117Article in journal (Refereed) Published
Abstract [en]

The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues. Overexpression of hyaluronan plays pivotal roles in inflammation and cancer, and markedly high serum and tissue levels of hyaluronan are noted under such pathological conditions. This review focuses on the complexity of the regulation at transcriptional and posttranslational level of hyaluronan synthetic enzymes, and the outcome of their aberrant expression and accumulation of hyaluronan in clinical conditions, such as systemic B-cell cancers, aggressive breast carcinomas, metabolic diseases and virus infection.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2019. Vol. 78-79, p. 100-117
National Category
Cell and Molecular Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-386169DOI: 10.1016/j.matbio.2018.01.017ISI: 000468707600008PubMedID: 29374576OAI: oai:DiVA.org:uu-386169DiVA, id: diva2:1327219
Funder
Swedish Cancer Society, CAN 2015/471Available from: 2019-06-19 Created: 2019-06-19 Last updated: 2019-06-19Bibliographically approved

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Heldin, ParaskeviLin, Chun-YuKolliopoulos, Constantinos

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Cell and Molecular BiologyMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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