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Peri-implant crevicular fluid proteome before and after adjunctive enamel matrix derivative treatment of peri-implantitis
Umea Univ, Dept Odontol, Umea, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Umea Univ, Dept Mol Periodontol, Umea, Sweden;Gavle Cty Hosp, Publ Dent Hlth Cty Council Gavleborg, Dept Periodontol, Gavle, Sweden.ORCID iD: 0000-0002-5327-8028
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Gavle Cty Hosp, Publ Dent Hlth Cty Council Gavleborg, Dept Periodontol, Gavle, Sweden.
Umea Univ, Dept Mol Periodontol, Umea, Sweden.
2019 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 46, no 6, p. 669-677Article in journal (Refereed) Published
Abstract [en]

Aim The aim of this study was to explore which peri-implant crevicular fluid (PICF) protein pattern is associated with the active peri-implantitis process. Materials and methods Peri-implant crevicular fluid from 25 peri-implantitis sites were subjected to proteomic analysis using liquid chromatography-tandem mass spectrometry before and at 3, 6 and 12 months after treatment, to identify associations between PICF protein pattern and implant loss, bleeding on probing, pocket depth and enamel matrix derivative (EMD) treatment. Results Clustering of subjects based on their 3-12 months PICF proteomic profiles by principal component analysis defined two major clusters. Cluster 2 differentiated from cluster 3 by 52 proteins (R-2 = 90%, Q(2) = 80%) and belonging to cluster 2 was associated with implant loss (p = 0.009) and bleeding on probing (p = 0.001). Cluster 3 was associated with implant survival and EMD treatment (p = 0.044). Conclusion Here, we demonstrate that a specific PICF proteomic profile associates with active peri-implantitis process and implant loss.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 46, no 6, p. 669-677
Keywords [en]
enamel matrix derivative, implant, peri-implantitis, proteome
National Category
Dentistry
Identifiers
URN: urn:nbn:se:uu:diva-385968DOI: 10.1111/jcpe.13108ISI: 000468314400008PubMedID: 30985016OAI: oai:DiVA.org:uu-385968DiVA, id: diva2:1327527
Available from: 2019-06-19 Created: 2019-06-19 Last updated: 2019-06-19Bibliographically approved

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Isehed, CatrineHolmlund, Anders

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