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Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis
Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany.
Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany;Univ Clermont Auvergne, Microbes Intestine Inflammat & Host Susceptibil, INRA 2018, UMR 1071 Inserm,USC, Clermont Ferrand, France.
Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany;German Ctr Infect Res DZIF, Partner Site LMU Munich, D-80336 Munich, Germany.
Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany;German Ctr Infect Res DZIF, Partner Site LMU Munich, D-80336 Munich, Germany.
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2019 (English)In: Cell Host and Microbe, ISSN 1931-3128, E-ISSN 1934-6069, Vol. 25, no 5, p. 681-694.e8Article in journal (Refereed) Published
Abstract [en]

The microbiota and the gastrointestinal mucus layer play a pivotal role in protection against non-typhoidal Salmonella enterica serovar Typhimurium (S. Tm) colitis. Here, we analyzed the course of Salmonella colitis in mice lacking a functional mucus layer in the gut. Unexpectedly, in contrast to mucus-proficient littermates, genetically deficient mice were protected against Salmonellainduced gut inflammation in the streptomycin colitis model. This correlated with microbiota alterations and enrichment of the bacterial phylum Deferribacteres. Using gnotobiotic mice associated with defined bacterial consortia, we causally linked Mucispirillum schaedleri, currently the sole known representative of Deferribacteres present in the mammalian microbiota, to host protection against S. Tm colitis. Inhibition by M. schaedleri involves interference with S. Tm invasion gene expression, partly by competing for anaerobic electron acceptors. In conclusion, this study establishes M. schaedleri, a core member of the murine gut microbiota, as a key antagonist of S. Tm virulence in the gut.

Place, publisher, year, edition, pages
2019. Vol. 25, no 5, p. 681-694.e8
National Category
Microbiology in the medical area Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-384068DOI: 10.1016/j.chom.2019.03.004ISI: 000467222600009PubMedID: 31006637OAI: oai:DiVA.org:uu-384068DiVA, id: diva2:1327875
Funder
Swedish Research Council, 2012-262Swedish Research Council, 2015-00635Swedish Foundation for Strategic Research , ICA16-0031EU, European Research Council, FunKeyGut 741623Available from: 2019-06-20 Created: 2019-06-20 Last updated: 2019-06-20Bibliographically approved

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Science for Life Laboratory, SciLifeLabDepartment of Medical Biochemistry and Microbiology
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Cell Host and Microbe
Microbiology in the medical areaMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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