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Concordance of Non-Low-Risk Disease Among Pairs of Brothers With Prostate Cancer
Karolinska Inst, Stockholm, Sweden;Danderyd Hosp, Stockholm, Sweden.
Reg Canc Ctr, Uppsala, Sweden.
Karolinska Inst, Stockholm, Sweden.ORCID iD: 0000-0002-5735-9626
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology. Uppsala Univ Hosp, Uppsala, Sweden.ORCID iD: 0000-0002-8306-0687
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2018 (English)In: Journal of Clinical Oncology, ISSN 0732-183X, E-ISSN 1527-7755, Vol. 36, no 18, p. 1847-1852Article in journal (Refereed) Published
Abstract [en]

Purpose: Prostate cancer among first-degree relatives is a strong risk factor for diagnosis of prostate cancer, and the contribution of heritable factors in prostate cancer etiology is high. We investigated how the concordance of non-low-risk prostate cancer among brothers is affected by their genetic relation.

Methods:We identified 4,262 pairs of brothers with prostate cancer in the Prostate Cancer Database Sweden. Their cancers were categorized as low risk (Gleason score 6; clinical stage T1-2, Nx/N0, Mx/M0; and prostate-specific antigen 10 ng/mL) or non-low risk. The odds ratio (OR) for concordance of non-low-risk cancer was calculated with logistic regression for the different types of fraternity (monozygotic twins, dizygotic twins, full brothers, and half-brothers)

Results: Among monozygotic twins who both were diagnosed with prostate cancer, the OR for both brothers being in the non-low-risk category was 3.82 (95% CI, 0.99 to 16.72) after adjusting for age and year of diagnosis. Among full brothers, the corresponding adjusted OR was 1.21 (95% CI, 1.04 to 1.39). When the analysis was restricted to brothers who both were diagnosed within 4 years, the results were similar.

Conclusion: Non-low-risk prostate cancer has a heritable pattern suggesting shared genetic factors, with the highest concordance among monozygotic twins. Our results suggest that a man whose brother has been diagnosed with a non-low-risk prostate cancer is at a clinically relevant increased risk of developing an aggressive prostate cancer himself.

Place, publisher, year, edition, pages
2018. Vol. 36, no 18, p. 1847-1852
National Category
Urology and Nephrology Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-387453DOI: 10.1200/JCO.2017.76.6907ISI: 000439452300012PubMedID: 29652556OAI: oai:DiVA.org:uu-387453DiVA, id: diva2:1330370
Funder
Swedish Cancer Society, CAN 2011/825Available from: 2019-06-25 Created: 2019-06-25 Last updated: 2019-06-25Bibliographically approved

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