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OLM alpha 2 Cells Bidirectionally Modulate Learning
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics. Univ Fed Rio Grande do Norte, Brain Inst, BR-59056450 Natal, RN, Brazil;Donders Inst Brain Behav & Cognit, NL-6525 EN Nijmegen, Gelderland, Netherlands.ORCID iD: 0000-0002-5836-1672
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
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2018 (English)In: Neuron, ISSN 0896-6273, E-ISSN 1097-4199, Vol. 99, no 2, p. 404-412Article in journal (Refereed) Published
Abstract [en]

Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor alpha 2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLM alpha 2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLM alpha 2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLM alpha 2 cell activation inhibits fear-related memories and that OLM alpha 2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLM alpha 2 cells are an important component in the CA1 microcircuit regulating learning and memory processes.

Place, publisher, year, edition, pages
CELL PRESS , 2018. Vol. 99, no 2, p. 404-412
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Neurosciences
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URN: urn:nbn:se:uu:diva-387269DOI: 10.1016/j.neuron.2018.06.022ISI: 000439709900017PubMedID: 29983324OAI: oai:DiVA.org:uu-387269DiVA, id: diva2:1331217
Funder
Swedish Research Council, 2015-02395Available from: 2019-06-26 Created: 2019-06-26 Last updated: 2019-06-26Bibliographically approved

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Siwani, SamerMikulovic, SanjaHilscher, Markus MLeão, Richardson NKullander, Klas

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Siwani, SamerFranca, Arthur S. C.Mikulovic, SanjaHilscher, Markus MLeão, Richardson NTort, Adriano B. L.Kullander, Klas
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