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Analysis of the complete human mtDNA genome: methodology and inferences for human evolution
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
2001 (English)In: Journal of Heredity, ISSN 0022-1503, E-ISSN 1465-7333, Vol. 92, no 6, 454-61 p.Article in journal (Refereed) Published
Abstract [en]

The analysis of mitochondrial DNA (mtDNA) sequences has been a potent tool in our understanding of human evolution. However, almost all studies of human evolution based on mtDNA sequencing have focused on the control region, which constitutes less than 7% of the mitochondrial genome. The rapid development of technology for automated DNA sequencing has made it possible to study the complete mtDNA genomes in large numbers of individuals, opening the field of mitochondrial population genomics. Here we describe a suitable methodology for determining the complete human mitochondrial sequence and the global mtDNA diversity in humans. Also, we discuss the implications of the results with respect to the different hypotheses for the evolution of modern humans.

Place, publisher, year, edition, pages
2001. Vol. 92, no 6, 454-61 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-87724PubMedID: 11948211OAI: oai:DiVA.org:uu-87724DiVA: diva2:133352
Available from: 2009-01-09 Created: 2009-01-09 Last updated: 2017-12-14Bibliographically approved

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