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Self-assembly in monoelaidin aqueous dispersions: direct vesicles to cubosomes transition
Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Physical Chemistry.
2008 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 3, no 11, e3747- p.Article in journal (Refereed) Published
Abstract [en]

Background: In the present study, synchrotron small-angle X-ray scattering (SAXS) and Cryo-TEM were used to characterize the temp.-induced structural transitions of monoelaidin (ME) aq. dispersion in the presence of the polymeric stabilizer F127. We prove that the direct transition from vesicles to cubosomes by heating this dispersion is possible. The obtained results were compared with the fully hydrated bulk ME phase. Methodol./Principal Findings: Our results indicate the formation of ME dispersion, which is less stable than that based on the congener monoolein (MO). In addn., the temp.-dependence behavior significantly differs from the fully hydrated bulk phase. SAXS findings indicate a direct Lalpha -V2 internal transition in the dispersion. While the transition temp. is conserved in the dispersion, the formed cubosomes with internal Im3m symmetry clearly contain more water and this ordered interior is retained over a wider temp. range as compared to its fully hydrated bulk system. At 25 DegC, Cryo-TEM observations reveal the formation of most likely closely packed onion-like vesicles. Above the lamellar to non-lamellar phase transition at 65 DegC, flattened cubosomes with an internal nanostructure are obsd. However, they have only arbitrary shapes and thus, their morphol. is significantly different from that of the well-shaped analogous MO cubosome and hexosome particles. Conclusions/Significance: Our study reveals a direct liposomes-cubosomes transition in ME dispersion. The obtained results suggest that the polymeric stabilizer F127 esp. plays a significant role in the membrane fusion processes. F127 incorporates in considerable amt. into the internal nanostructure and leads to the formation of a highly swollen Im3m phase.

Place, publisher, year, edition, pages
2008. Vol. 3, no 11, e3747- p.
National Category
Natural Sciences
Research subject
Physical Chemistry
URN: urn:nbn:se:uu:diva-87776DOI: 10.1371/journal.pone.0003747ISI: 000265448400004PubMedID: 19015726OAI: oai:DiVA.org:uu-87776DiVA: diva2:133590
Available from: 2009-01-13 Created: 2009-01-13 Last updated: 2010-12-18Bibliographically approved

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