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The Healing Power of Neutrophils
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.ORCID iD: 0000-0002-2387-0266
Univ Calgary, Snyder Inst Infect Immun & Inflammat, Calgary, AB T2N 4N1, Canada;Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada.
2019 (English)In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 40, no 7, p. 635-647Article, review/survey (Refereed) Published
Abstract [en]

Neutrophils promptly accumulate in large numbers at sites of tissue injury. Injuries to the skin or mucosae disrupt barriers against the external environment, and the bactericidal actions of neutrophils are important in preventing microbial invasion. Neutrophils have also been associated with exacerbated inflammation, for example in non-healing wounds or in conditions such as inflammatory bowel disease (IBD). However, additional neutrophil functions important for angiogenesis and tissue restoration have been uncovered in models of sterile and ischemic injury, as well as in tumors. These functions are also relevant in healing skin and mucosal wounds, and can be impaired in conditions associated with non-healing wounds, such as diabetes. Here, we discuss our current understanding of neutrophil contributions to healing, and how the latter can be compromised in disease.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 40, no 7, p. 635-647
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-390330DOI: 10.1016/j.it.2019.05.001ISI: 000473003200010PubMedID: 31160208OAI: oai:DiVA.org:uu-390330DiVA, id: diva2:1341684
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationRagnar Söderbergs stiftelseErnfors FoundationSwedish Diabetes AssociationAvailable from: 2019-08-09 Created: 2019-08-09 Last updated: 2019-08-09Bibliographically approved

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