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Memory consolidation impairment induced by Interleukin-1 beta is associated with changes in hippocampal structural plasticity
Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, IFEC CONICET, Haya de la Torre & Medina Allende Ciudad Univ, RA-5000 Cordoba, Argentina.
Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, IFEC CONICET, Haya de la Torre & Medina Allende Ciudad Univ, RA-5000 Cordoba, Argentina.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Schiöth: Functional Pharmacology. Sechenov First Moscow State Med Univ, Inst Translat Med & Biotechnol, Moscow, Russia.ORCID iD: 0000-0001-7112-0921
Inst Invest Biomed INBIOMED UBA CONICET, Fac Med, Buenos Aires, DF, Argentina.
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2019 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 370, article id 111969Article in journal (Refereed) Published
Abstract [en]

Pro-inflammatory cytokines, particularly Interleukin-1 beta (IL-1 beta), can affect cognitive processes such as learning and memory. The aim of this study was to establish whether the effect of IL-1 beta on contextual fear memory is associated with changes in hippocampal structural plasticity. We also studied the effect of alpha-melanocyte-stimulating hormone (alpha-MSH), a potent anti-inflammatory and neuro-protective peptide. Different groups of animals were implanted bilaterally in dorsal hippocampus (DH). After recovery they were conditioned for contextual fear memory and received the different treatments (vehicle, IL-1 beta, alpha-MSH or IL-1 beta + alpha-MSH). Memory was assessed 24 hs after conditioning and immediately after rats were perfused for dendritic spine analysis. Our results show that local hippocampal administration of IL-1 beta just after memory encoding induced impairment in contextual memory and a reduction in the total density of CA1 hippocampal dendritic spines, particularly the mature ones. alpha-MSH administration reversed the IL-1 beta induced changes. The results suggest that neuro-inflammation induced by IL-1 beta interferes with experience-dependent structural plasticity in DH whereas alpha-MSH has a beneficial modulatory role in preventing this effect.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2019. Vol. 370, article id 111969
Keywords [en]
IL-1 beta, alpha-MSH, Dendritic spines, Dorsal hippocampus
National Category
Neurology Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-390371DOI: 10.1016/j.bbr.2019.111969ISI: 000474323900023PubMedID: 31128164OAI: oai:DiVA.org:uu-390371DiVA, id: diva2:1341808
Funder
Swedish Research Council, 2016-01088Available from: 2019-08-12 Created: 2019-08-12 Last updated: 2019-08-12Bibliographically approved

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