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Effect of acute endolymphatic hydrops overload on the endolymphatic sac
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2008 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 128, no 3, 239-44 p.Article in journal (Refereed) Published
Abstract [en]

CONCLUSIONS: Homeostasis of endolymph volume is a complex mechanism, in which the endolymphatic sac (ES) may play an important role. OBJECTIVES: To elucidate the effect of acute endolymphatic hydrops (EH) on the ES and to gain further information about the volume and pressure regulative function of the ES. MATERIALS AND METHODS: Distilled water was injected into the middle ear cavity of adult CBA/J mice. The ESs were studied morphologically by light and transmission electron microscopy. RESULTS: Mild EH was found, particularly in the upper turn of the cochlea. Acute EH led to an increase in the size of the ES lumen, accompanied by collapse of the lateral intercellular spaces and dense perisaccular tissue, changes which had reversed 2 h after the injection.

Place, publisher, year, edition, pages
2008. Vol. 128, no 3, 239-44 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-88034DOI: 10.1080/00016480701497428ISI: 000254394300003PubMedID: 17851910OAI: oai:DiVA.org:uu-88034DiVA: diva2:134188
Available from: 2009-01-19 Created: 2009-01-19 Last updated: 2017-12-14Bibliographically approved

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