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A new animal model for Ménière's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2008 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 128, no 3, 263-71 p.Article in journal (Refereed) Published
Abstract [en]

CONCLUSION: A new murine model for the study of Ménière's disease has been developed by treatment with both lipopolysaccharide (LPS) and aldosterone. Induction of vestibular dysfunction in the hydropic animal model may entail additional stress such as reduced inner ear blood flow, and sudden acute changes in endolymph volume and/or pressure. OBJECTIVE: The purpose of this study was to develop a more suitable animal model, showing closer resemblance to the pathophysiological process in Ménière's disease. MATERIALS AND METHODS: Adult CBA/J mice were treated by intratympanic injection of LPS, intraperitoneal injection of aldosterone, or injection of both LPS and aldosterone. Morphological analyses were performed in the cochlea and endolymphatic sac. RESULTS: All experimental animals showed mild to moderate endolymphatic hydrops. Those treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.

Place, publisher, year, edition, pages
2008. Vol. 128, no 3, 263-71 p.
Keyword [en]
Ménière´s disease
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-88036DOI: 10.1080/00016480701497436ISI: 000254394300007PubMedID: 17851960OAI: oai:DiVA.org:uu-88036DiVA: diva2:134190
Available from: 2009-01-19 Created: 2009-01-19 Last updated: 2017-12-14Bibliographically approved

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