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Evaluation of an alkali-treated and hydroxyapatite-coated orthopedic implant loaded with tobramycin
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Doctores Sorensen OHG, Segeberger Landstr, Kiel, Germany.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.ORCID iD: 0000-0002-5496-9664
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.ORCID iD: 0000-0001-9529-650X
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2019 (English)In: Journal of biomaterials applications, ISSN 0885-3282, E-ISSN 1530-8022, Vol. 34, no 5, p. 699-720, article id UNSP 0885328219867968Article in journal (Refereed) Published
Abstract [en]

An approximately 1-µm thick hydroxyapatite coating was biomimetically deposited on an alkali-treated, commercially available orthopedic screw surface (type II anodized titanium). Tobramycin loaded into the coating via a simple soaking method was shown to provide a sustained release above the minimal inhibitory concentration 0.2 µg/µl for up to two days. Agar diffusion tests showed that the tobramycin-loaded coating was able to produce a zone of inhibition against Staphylococcus aureus for up to five days. Biocompatibility testing using outgrowth endothelial cells and primary osteoblasts suggested that good cell compatibility of the coating can be expected in vivo. A rabbit distal femur condyle model was used for in vivo evaluation of the antibacterial efficacy of the tobramycin-loaded coating, and this pilot study showed that the release of tobramycin was sufficient to locally eliminate very large amounts of bacteria in vivo (inoculation dose 104–105 CFU S. aureus/test site).

Place, publisher, year, edition, pages
2019. Vol. 34, no 5, p. 699-720, article id UNSP 0885328219867968
Keywords [en]
Hydroxyapatite, antibacterial, orthopedic implant, tobramycin, fixation screw
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Materials Science
Identifiers
URN: urn:nbn:se:uu:diva-390827DOI: 10.1177/0885328219867968ISI: 000482810300001PubMedID: 31408413OAI: oai:DiVA.org:uu-390827DiVA, id: diva2:1342781
Funder
EU, FP7, Seventh Framework ProgrammeAvailable from: 2019-08-14 Created: 2019-08-14 Last updated: 2019-10-30Bibliographically approved

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Janson, OscarStrömme, MariaEngqvist, HåkanProcter, PhilipWelch, Ken

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