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Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia
Ctr Res & Technol Hellas, Inst Appl Biosci, 6th Km Charilaou Thermi Rd, GR-57001 Thessaloniki, Greece;Univ Ioannina, Dept Biol Applicat & Technol, Ioannina, Greece.
Ctr Res & Technol Hellas, Inst Appl Biosci, 6th Km Charilaou Thermi Rd, GR-57001 Thessaloniki, Greece.
Ctr Res & Technol Hellas, Inst Appl Biosci, 6th Km Charilaou Thermi Rd, GR-57001 Thessaloniki, Greece.
Univ Vita Salute San Raffaele, Div Expt Oncol, Strateg Res Program CLL & B Cell Neoplasia Unit, Milan, Italy;IRCCS Ist Sci San Raffaele, Milan, Italy.
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2019 (English)In: BLOOD ADVANCES, ISSN 2473-9529, Vol. 3, no 12, p. 1891-1896Article in journal (Refereed) Published
Abstract [en]

Key Points:

Microenvironmental stimuli affect EZH2 expression and function in CLL.Combined B-cell signaling and EZH2 inhibition showed synergistic effects on primary CLL cells.

Place, publisher, year, edition, pages
AMER SOC HEMATOLOGY , 2019. Vol. 3, no 12, p. 1891-1896
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Hematology
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URN: urn:nbn:se:uu:diva-390824DOI: 10.1182/bloodadvances.2018030262ISI: 000472782500013PubMedID: 31227476OAI: oai:DiVA.org:uu-390824DiVA, id: diva2:1342902
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Swedish Research CouncilKnut and Alice Wallenberg FoundationAvailable from: 2019-08-14 Created: 2019-08-14 Last updated: 2019-08-14Bibliographically approved

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Rosenquist, Richard

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