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Gene expression profiling suggests differences in molecular mechanisms of fin elongation between cichlid species
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology. Karl Franzens Univ Graz, Inst Biol, Univ Pl 2, A-8010 Graz, Austria.ORCID iD: 0000-0002-6528-1187
Karl Franzens Univ Graz, Inst Biol, Univ Pl 2, A-8010 Graz, Austria.
Karl Franzens Univ Graz, Inst Biol, Univ Pl 2, A-8010 Graz, Austria.ORCID iD: 0000-0002-6482-9251
Karl Franzens Univ Graz, Inst Biol, Univ Pl 2, A-8010 Graz, Austria.
2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 9052Article in journal (Refereed) Published
Abstract [en]

Comparative analyses of gene regulation inform about the molecular basis of phenotypic trait evolution. Here, we address a fin shape phenotype that evolved multiple times independently across teleost fish, including several species within the family Cichlidae. In a previous study, we proposed a gene regulatory network (GRN) involved in the formation and regeneration of conspicuous filamentous elongations adorning the unpaired fins of the Neolamprologus brichardi. Here, we tested the members of this network in the blockhead cichlid, Steatocranus casuarius, which displays conspicuously elongated dorsal and moderately elongated anal fins. Our study provided evidence for differences in the anatomy of fin elongation and suggested gene regulatory divergence between the two cichlid species. Only a subset of the 20 genes tested in S. casuarius showed the qPCR expression patterns predicted from the GRN identified in N. brichardi, and several of the gene-by-gene expression correlations differed between the two cichlid species. In comparison to N. brichardi, gene expression patterns in S. casuarius were in better (but not full) agreement with gene regulatory interactions inferred in zebrafish. Within S. casuarius, the dorsoventral asymmetry in ornament expression was accompanied by differences in gene expression patterns, including potential regulatory differentiation, between the anal and dorsal fin.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, article id 9052
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Evolutionary Biology
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URN: urn:nbn:se:uu:diva-390679DOI: 10.1038/s41598-019-45599-wISI: 000472477700007PubMedID: 31227799OAI: oai:DiVA.org:uu-390679DiVA, id: diva2:1343059
Available from: 2019-08-15 Created: 2019-08-15 Last updated: 2019-08-15Bibliographically approved

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Ahi, Ehsan Pashay

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