uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Respiratory system inertance corresponds to extravascular lung water in surfactant-deficient piglets
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care. (Anaesthesiology and intensive care)
Show others and affiliations
2008 (English)In: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 160, no 3, 313-9 p.Article in journal (Refereed) Published
Abstract [en]

In various cardio-pulmonary diseases lung mass is considerably increased due to intrapulmonary fluid accumulation, i.e. extravascular lung water (EVLW). Generally, inertance is a physical system parameter that is mass-dependent. We hypothesized that changes in lung mass influence the inertive behavior of the respiratory system. EVLW and intrathoracic blood volume (ITBV) were compared with respiratory system inertance (I(rs)) in four piglets before and after broncho-alveolar lavage (BAL) that induced surfactant deficiency with interstitial edema. EVLW and ITBV were determined using the double-indicator dilution technique, I(rs) by multiple linear regression analysis. Measurements were taken before, and 1 and 2 h after BAL. EVLW increased threefold (from 6.2+/-0.8 mL/kg at baseline to 17.7+/-0.9 mL/kg (p < 0.001) after BAL). I(rs) increased by 35% (from 0.17+/-0.02 to 0.23+/-0.04 cmH(2)O s(2)/L (p = 0.036) after BAL) and was tightly correlated to EVLW (r(2) = 0.95, p < 0.023). ITBV did not change significantly after BAL. We conclude that I(rs) reflects actual changes in lung mass and thus hints at fluid accumulation within the lung.

Place, publisher, year, edition, pages
2008. Vol. 160, no 3, 313-9 p.
Keyword [en]
Broncho-alveolar lavage, Lung mass, Multiple linear regression analysis, Respiratory system compliance
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-88095DOI: 10.1016/j.resp.2007.10.015ISI: 000254770600009PubMedID: 18068554OAI: oai:DiVA.org:uu-88095DiVA: diva2:134352
Available from: 2009-01-20 Created: 2009-01-20 Last updated: 2015-06-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lichtwarck-Aschoff, Michael
By organisation
Anaesthesiology and Intensive Care
In the same journal
Respiratory Physiology & Neurobiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 194 hits
ReferencesLink to record
Permanent link

Direct link