uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Nanotechnologic biosensor ellipsometry and biomarker pattern analysis in the evaluation of atherosclerotic risk profile.
Charité – University Clinic Berlin, Institute of Physiology, Berlin, Germany.
Charité – University Clinic Berlin, Institute of Physiology, Berlin, Germany.
Charité – University Clinic Berlin, Institute of Physiology, Berlin, Germany.
Novartis Pharma, Nürnberg, Germany.
Show others and affiliations
2009 (English)In: Biosensors & bioelectronics, ISSN 1873-4235, Vol. 24, no 5, 1512-1517 p.Article in journal (Refereed) Published
Abstract [en]

A proteoheparan sulfate coated, hydrophobic silica surface serves as lipoprotein receptor at which the Ca(2+)-driven arteriosclerotic nanoplaque formation can be pursued by laser-based ellipsometry. Any lipoprotein from human blood can be very sensitively tested for its atherogenic properties. From the same blood sample, it is possible to determine the concentration and activity of a series of interacting biomarker molecules which, through a pattern analysis, allow to assess the state of health with respect to cardiovascular diseases. These two interlinked and complementary biosensors make a prospective cardio-cerebro-vascular risk stratification feasible, especially the sequelae of an underlying arteriosclerotic disease. Based on these diagnostic tools, an optimized therapy decision for the patient can be taken and the necessary preventive measures for the still healthy person.

Place, publisher, year, edition, pages
2009. Vol. 24, no 5, 1512-1517 p.
Keyword
Nanotechnologic biosensor ellipsometry, biomarker pattern analysis, atherosclerotic risk profile, statins -3 fatty acids, ginkgo biloba
Identifiers
URN: urn:nbn:se:uu:diva-88118DOI: 10.1016/j.bios.2008.08.011PubMedID: 18809309OAI: oai:DiVA.org:uu-88118DiVA: diva2:134453
Available from: 2009-01-21 Created: 2009-01-21 Last updated: 2009-02-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Pharmacy

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 514 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf