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Nanometre-sized droplets from a gas dynamic virtual nozzle
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics.
Univ Seville, ETSI, Dept Ingn Aerospacial & Mecan Fluidos, ES-41092 Seville, Spain.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics. Acad Sci Czech Republ, Inst Phys, ELI Beamlines, CZ-18221 Prague, Czech Republic;Chalmers Univ Technol, Dept Phys, Condensed Matter Phys, SE-41258 Gothenburg, Sweden.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics.ORCID iD: 0000-0002-3573-3023
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2019 (English)In: Journal of applied crystallography, ISSN 0021-8898, E-ISSN 1600-5767, Vol. 52, p. 800-808Article in journal (Refereed) Published
Abstract [en]

This paper reports on improved techniques to create and characterize nanometre-sized droplets from dilute aqueous solutions by using a gas dynamic virtual nozzle (GDVN). It describes a method to measure the size distribution of uncharged droplets, using an environmental scanning electron microscope, and provides theoretical models for the droplet sizes created. The results show that droplet sizes can be tuned by adjusting the gas and liquid flow rates in the GDVN, and at the lowest liquid flow rates, the size of the water droplets peaks at about 120nm. This droplet size is similar to droplet sizes produced by electrospray ionization but requires neither electrolytes nor charging of the solution. The results presented here identify a new operational regime for GDVNs and show that predictable droplet sizes, comparable to those obtained by electrospray ionization, can be produced by purely mechanical means in GDVNs.

Place, publisher, year, edition, pages
INT UNION CRYSTALLOGRAPHY , 2019. Vol. 52, p. 800-808
Keywords [en]
aerosols, droplet size, gas dynamic virtual nozzles (GDVNs), environmental scanning electron microscopy, coherent X-ray diffractive imaging (CXDI), single particles, sample delivery, structural biology, nanoscience
National Category
Physical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-391281DOI: 10.1107/S1600576719008318ISI: 000477717400013OAI: oai:DiVA.org:uu-391281DiVA, id: diva2:1345005
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationEU, European Research CouncilAvailable from: 2019-08-22 Created: 2019-08-22 Last updated: 2019-08-22Bibliographically approved

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Mühlig, KerstinAndreasson, JakobLarsson, Daniel S DHajdu, JanosSvenda, Martin

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