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Evaluation of quantitative CMR perfusion imaging by comparison with simultaneous 15O-water-PET.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
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2019 (English)In: Journal of Nuclear Cardiology, ISSN 1071-3581, E-ISSN 1532-6551Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: We assessed the quantitative accuracy of cardiac perfusion measurements using dynamic contrast-enhanced MRI with simultaneous 15O-water PET as reference with a fully integrated PET-MR scanner.

METHODS: 15 patients underwent simultaneous DCE MRI and 15O-water PET scans at rest and adenosine-stress on an integrated PET-MR scanner. Correlation and agreement between MRI- and PET-based global and regional MBF values were assessed using correlation and Bland-Altman analysis.

RESULTS: Three subjects were excluded due to technical problems. Global mean (± SD) MBF values at rest and stress were 0.97 ± 0.27 and 3.19 ± 0.70 mL/g/min for MRI and 1.02 ± 0.28 and 3.13 ± 1.16 mL/g/min for PET (P = 0.66 and P = 0.81). The correlations between global and regional MRI- and PET-based MBF values were strong (r = 0.86 and r = 0.75). The biases were negligible for both global and regional MBF comparisons (0.01 and 0.00 mL/min/g for both), but the limits of agreement were wide for both global and regional MBF, with larger variability for high MBF-values.

CONCLUSION: The correlation between simultaneous MBF measurements with DCE MRI and 15O-water PET measured in an integrated PET-MRI was strong but the agreement was only moderate indicating that MRI-based quantitative MBF measurements is not ready for clinical introduction.

Place, publisher, year, edition, pages
2019.
Keywords [en]
Myocardial perfusion, cardiac magnetic resonance imaging, myocardial blood flow, positron emission tomography, quantitative modelling
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-392830DOI: 10.1007/s12350-019-01810-zPubMedID: 31313066OAI: oai:DiVA.org:uu-392830DiVA, id: diva2:1349961
Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-09-10

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