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Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction.
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2019 (English)In: Journal of Nuclear Cardiology, ISSN 1071-3581, E-ISSN 1532-6551Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Assessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and perfusable tissue index (PTI) in the assessment of myocardial viability in a pig model of myocardial infarction (MI).

METHODS AND RESULTS: Pigs underwent resting [15O]water PET perfusion study 12 weeks after surgical (n = 16) or 2 weeks after catheter-based (n = 4) occlusion of the proximal left anterior descending coronary artery. MBF, PTF, and PTI were compared with volume fraction of MI in matched segments as assessed by triphenyl tetrazolium chloride staining of LV slices. MBF and PTF were lower in infarcted than non-infarcted segments. Segmental analysis of MBF showed similar area under the curve (AUC) of 0.85, 0.86, and 0.90 with relative MBF, PTF, and PTI for the detection of viable myocardium defined as infarct volume fraction of < 75%. Cut-off values of relative MBF of ≥ 67% and PTF of ≥ 66% resulted in accuracies of 90% and 81%, respectively.

CONCLUSIONS: Our results indicate that resting MBF, PTF, and PTI based on [15O]water PET perfusion imaging are useful for the assessment of myocardial viability.

Place, publisher, year, edition, pages
2019.
Keywords [en]
PET, Radiowater, myocardial infarction, myocardial perfusion imaging, viability
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-392840DOI: 10.1007/s12350-019-01818-5PubMedID: 31317328OAI: oai:DiVA.org:uu-392840DiVA, id: diva2:1349992
Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-09-10

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