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Investigating Maternal Brain Alterations in Preeclampsia: the Need for a Multidisciplinary Effort
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Obstetrics.ORCID iD: 0000-0001-5202-9428
Univ Concepcion, Fac Pharm, Pharm Dept, Concepcion, Chile ;Grp Res & Innovat Vasc Hlth GRIVAS Hlth, Chillan, Chile.
Univ Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Div Pharm & Optometry, Manchester, Lancs, England.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.ORCID iD: 0000-0002-9481-6857
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2019 (English)In: Current Hypertension Reports, ISSN 1522-6417, E-ISSN 1534-3111, Vol. 21, no 9, article id 72Article in journal (Refereed) Published
Abstract [en]

PURPOSE OF REVIEW: To provide insight into the mechanisms underlying cerebral pathophysiology and to highlight possible methods for evaluation, screening, and surveillance of cerebral complications in preeclampsia.

RECENT FINDINGS: The pathophysiology of eclampsia remains enigmatic. Animal studies show that the cerebral circulation in pregnancy and preeclampsia might be affected with increased permeability over the blood-brain barrier and altered cerebral blood flow due to impaired cerebral autoregulation. The increased blood pressure cannot be the only underlying cause of eclampsia and cerebral edema, since some cases of eclampsia arise without simultaneous hypertension. Findings from animal studies need to be confirmed in human tissues. Evaluation of brain alterations in preeclampsia and eclampsia is challenging and demands a multidisciplinary collaboration, since no single method can accurately and fully describe how preeclampsia affects the brain. Cerebral complications of preeclampsia are significant factors in maternal morbidity and mortality worldwide. No single method can accurately describe the full picture of how preeclampsia affects the brain vasculature and parenchyma. We recommend an international and multidisciplinary effort not only to overcome the issue of limited sample availability but also to optimize the quality of research.

Place, publisher, year, edition, pages
2019. Vol. 21, no 9, article id 72
Keywords [en]
Biomarkers, Blood-brain barrier, Brain complications, Brain imaging, Eclampsia, Preclinical studies, Preeclampsia
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-392990DOI: 10.1007/s11906-019-0977-0ISI: 000479197200001PubMedID: 31375930OAI: oai:DiVA.org:uu-392990DiVA, id: diva2:1350850
Available from: 2019-09-12 Created: 2019-09-12 Last updated: 2019-09-25Bibliographically approved

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Bergman, LinaWikström, JohanNelander, MariaWikström, Anna-Karin

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