uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis
Akershus Univ Hosp, Dept Cardiol, Div Med, Lorenskog, Norway;Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway.
Akershus Univ Hosp, Dept Cardiol, Div Med, Lorenskog, Norway;Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway.
Akershus Univ Hosp, Dept Cardiol, Div Med, Lorenskog, Norway;Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway.
Univ Oslo, Ctr Heart Failure Res, Inst Clin Med, Oslo, Norway;Oslo Univ Hosp, Rikshosp, Dept Cardiol, Oslo, Norway.
Show others and affiliations
2019 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 71, p. 17-23Article in journal (Refereed) Published
Abstract [en]

Background: Secretoneurin (SN) concentrations provide important prognostic information in patients with myocardial dysfunction. Whether preoperative SN concentrations improve risk assessment in patients with moderate to severe aortic stenosis (AS) is unknown. Methods: We included 57 patients with moderate to severe AS referred for presurgical evaluation. All patients were examined with comprehensive echocardiography, electrocardiogram (ECG), and biochemical measurements and compared to 10 age- and sex-matched healthy subjects. Results: Median (quartile 1-3) SN concentrations were 141 (121-163) pmol/L in AS patients and 132 (106-148) pmol/L in control subjects (p = .17). Lower estimated creatinine clearance and use of diuretics, but not standard ECG or echocardiographic indices and cardiac biomarkers, were associated with increasing SN concentrations. Fifteen patients (26%) died during 3.5 years median follow-up. SN concentrations were higher in non-survivors than survivors: 156 (133-209) vs. 140 (116-155) pmol/L, p = .007. Higher SN concentrations were associated with increased risk of mortality also after adjustment for established risk indices, biomarkers, and status regarding valvular surgery: hazard ratio per lnSN 15.13 (95% CI 1.05-219.00); p = .046. Receiver operating characteristics area under the curve for SN to predict mortality was 0.74 (95% CI 0.60-0.88) compared to 0.73 (0.59-0.87) for high-sensitivity cardiac troponin T and 0.67 (0.51-0.82) for N-terminal pro-B-type natriuretic peptide. The previously identified cut-off of SN > 204 pmol/L in cardiac surgical patients predicted mortality also in this cohort. Conclusions: SN concentrations improve risk assessment in patients with moderate to severe AS by providing additional prognostic information to established risk indices such as echocardiography, ECG, and established cardiac biomarkers.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2019. Vol. 71, p. 17-23
Keywords [en]
Aortic stenosis, Biomarkers, Secretoneurin, Cardiac surgery, Echocardiography
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-393647DOI: 10.1016/j.clinbiochem.2019.06.008ISI: 000480675200003PubMedID: 31228433OAI: oai:DiVA.org:uu-393647DiVA, id: diva2:1354728
Available from: 2019-09-26 Created: 2019-09-26 Last updated: 2019-09-26Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Stridsberg, Mats

Search in DiVA

By author/editor
Stridsberg, Mats
By organisation
Biochemical endocrinology
In the same journal
Clinical Biochemistry
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 52 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf