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Introduction and Dispersal of Sindbis Virus from Central Africa to Europe
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Univ Helsinki, Med, Dept Virol, Helsinki, Finland;Univ Helsinki, Helsinki, Finland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala Univ, Zoonosis Sci Ctr, Dept Med Biochem & Microbiol, Uppsala, Sweden;Nedre Dalalven Utvecklings AB, Biolog Myggkontroll, Uppsala, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.ORCID iD: 0000-0001-6665-7492
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2019 (English)In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 93, no 16, article id e00620-19Article in journal (Refereed) Published
Abstract [en]

Bird-hosted viruses have the potential to be transported over large areas of the world and to be transmitted in distant geographical regions. Sindbis virus (SINV) is a mosquito-borne alphavirus that is locally amplified in a bird-mosquito enzootic cycle and distributed all over the Old World and Australia/Oceania. Sindbis virus genotype I (SINV-I) is the cause of disease outbreaks in humans in South Africa as well as in northern Europe. To trace the evolutionary history and potential strain-disease association of SINV-I, we sequenced 36 complete genomes isolated from field material in Europe, as well as in Africa and the Middle East, collected over 58 years. These were analyzed together with 30 additional published whole SINV-I genomes using Bayesian analysis. Our results suggested that SINV-I was introduced only once to northern Europe from central Africa, in the 1920s. After its first introduction to Sweden, it spread east and southward on two separate occasions in the 1960s and 1970s. Another introduction from central Africa to southern/central Europe seems to have occurred, and where these two introductions meet, one recombination event was detected in central Europe. In addition, another recombinant strain was found in central Africa, where the most divergent SINV-I strains also originated. IMPORTANCE This study shows that only a single introduction of SINV into a new geographical area is required for spread and establishment, provided that the requisite vector(s) and reservoir(s) of epizootological and epidemiological importance are present. Furthermore, we present the first report of recombination between two strains of SINV in nature. Our study increases the knowledge on new introductions and dispersal of arboviruses in general and of SINV in particular.

Place, publisher, year, edition, pages
AMER SOC MICROBIOLOGY , 2019. Vol. 93, no 16, article id e00620-19
Keywords [en]
evolution, phylogeny, Sindbis virus
National Category
Zoology
Identifiers
URN: urn:nbn:se:uu:diva-393619DOI: 10.1128/JVI.00620-19ISI: 000480711400020PubMedID: 31142666OAI: oai:DiVA.org:uu-393619DiVA, id: diva2:1355006
Funder
Swedish Research Council, 2017-05807Swedish Research Council Formas, 2015-710Available from: 2019-09-26 Created: 2019-09-26 Last updated: 2019-09-26Bibliographically approved

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Ling, JiaxinLundström, Jan OPettersson, JohnLundkvist, ÅkeHesson, Jenny C.

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