uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep
Chinese Acad Agr Sci, Key Laborary Anim Genet Breeding & Reprod Poultry, Inst Anim Sci, Minist Agr, Beijing 100193, Peoples R China.
Aarhus Univ, Dept Mol Biol & Genet, Ctr Quantitat Genet & Genom, Tjele, Denmark.ORCID iD: 0000-0002-6018-0766
Aarhus Univ, Dept Mol Biol & Genet, Ctr Quantitat Genet & Genom, Tjele, Denmark.ORCID iD: 0000-0001-7608-7577
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.ORCID iD: 0000-0001-5571-4578
Show others and affiliations
2019 (English)In: Journal of Animal Breeding and Genetics, ISSN 0931-2668, E-ISSN 1439-0388, Vol. 136, no 5, p. 362-370Article in journal (Refereed) Published
Abstract [en]

Fat-tailed sheep have a unique characteristic of depositing fat in their tails. In the present study, we conducted genome-wide association studies (GWAS) on traits related to tail fat deposition and body size in the Hulun Buir sheep. A total number of 300 individuals belonging to two fat-tailed lines of the Hulun Buir sheep breed genotyped with the Ovine Infinium HD SNP BeadChip were included in the current study. Two mixed models, one for continuous and one for binary phenotypic traits, were employed to analyse ten traits, that is, body length (BL), body height (BH), chest girth (CG), tail length (TL), tail width (TW), tail circumference (TC), carcass weight (CW), tail fat weight (TF), ratio of CW to TF (RCT) and tail type (TT). We identified 7, 6, 7, 2, 10 and 1 SNPs significantly associated with traits TF, CW, RCT, TW, TT and CG, respectively. Their associated genomic regions harboured 42 positional candidate genes. Out of them, 13 candidate genes including SMURF2, FBF1, DTNBP1, SETD7 and RBM11 have been associated with fat metabolism in sheep. The RBM11 gene has already been identified in a previous study on signatures of selection in this specific sheep population. Two more genes, that is, SMARCA5 and GAB1 were associated with body size in sheep. The present study has identified candidate genes that might be implicated in tail fat deposition and body size in sheep.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 136, no 5, p. 362-370
Keywords [en]
candidate genes, fat deposition, genome-wide association study, Hulun Buir sheep, tail type
National Category
Genetics and Breeding in Agricultural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-394064DOI: 10.1111/jbg.12402ISI: 000482239300008PubMedID: 31045295OAI: oai:DiVA.org:uu-394064DiVA, id: diva2:1356769
Available from: 2019-10-02 Created: 2019-10-02 Last updated: 2019-10-02Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Zan, Yanjun

Search in DiVA

By author/editor
Gao, HongdingSahana, GoutamZan, Yanjun
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
Journal of Animal Breeding and Genetics
Genetics and Breeding in Agricultural Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 7 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf