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Treatment Outcomes of Colistin- and Carbapenem-resistant Acinetobacter baumannii Infections: An Exploratory Subgroup Analysis of a Randomized Clinical Trial
Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel.
Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Sourasky Med Ctr, Mol Epidemiol Lab, Tel Aviv, Israel.
Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Sourasky Med Ctr, Mol Epidemiol Lab, Tel Aviv, Israel.
Minist Hlth, Natl Inst Antibiot Resistance & Infect Control, Tel Aviv, Israel;Tel Aviv Sourasky Med Ctr, Mol Epidemiol Lab, Tel Aviv, Israel.
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2019 (English)In: Clinical Infectious Diseases, ISSN 1058-4838, E-ISSN 1537-6591, Vol. 69, no 5, p. 769-776Article in journal (Refereed) Published
Abstract [en]

Background We evaluated the association between mortality and colistin resistance in Acinetobacter baumannii infections and the interaction with antibiotic therapy. Methods This is a secondary analysis of a randomized controlled trial of patients with carbapenem-resistant gram-negative bacterial infections treated with colistin or colistin-meropenem combination. We evaluated patients with infection caused by carbapenem-resistant A. baumannii (CRAB) identified as colistin susceptible (CoS) at the time of treatment and compared patients in which the isolate was confirmed as CoS with those whose isolates were retrospectively identified as colistin resistant (CoR) when tested by broth microdilution (BMD). The primary outcome was 28-day mortality. Results Data were available for 266 patients (214 CoS and 52 CoR isolates). Patients with CoR isolates had higher baseline functional capacity and lower rates of mechanical ventilation than patients with CoS isolates. All-cause 28-day mortality was 42.3% (22/52) among patients with CoR strains and 52.8% (113/214) among patients with CoS isolates (P = .174). After adjusting for variables associated with mortality, the mortality rate was lower among patients with CoR isolates (odds ratio [OR], 0.285 [95% confidence interval {CI}, .118-.686]). This difference was associated with treatment arm: Mortality rates among patients with CoR isolates were higher in those randomized to colistin-meropenem combination therapy compared to colistin monotherapy (OR, 3.065 [95% CI, 1.021-9.202]). Conclusions Colistin resistance determined by BMD was associated with lower mortality among patients with severe CRAB infections. Among patients with CoR isolates, colistin monotherapy was associated with a better outcome compared to colistin-meropenem combination therapy.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS INC , 2019. Vol. 69, no 5, p. 769-776
Keywords [en]
Acinetobacter, carbapenem-resistant, colistin, gram-negative bacteria, XDR-TB
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-394059DOI: 10.1093/cid/ciy988ISI: 000482420100006PubMedID: 30462182OAI: oai:DiVA.org:uu-394059DiVA, id: diva2:1356779
Funder
EU, FP7, Seventh Framework Programme, Health-F3-2011-278348Available from: 2019-10-02 Created: 2019-10-02 Last updated: 2019-10-02Bibliographically approved

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