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The role of H3K79 methylation in transcription and the DNA damage response
Univ Michigan, Comprehens Canc Ctr, Ctr RNA Biomed, Dept Radiat Oncol, Ann Arbor, MI 48109 USA;Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. Univ Michigan, Comprehens Canc Ctr, Ctr RNA Biomed, Dept Radiat Oncol, Ann Arbor, MI 48109 USA.
Univ Michigan, Comprehens Canc Ctr, Ctr RNA Biomed, Dept Radiat Oncol, Ann Arbor, MI 48109 USA.
Univ Michigan, Comprehens Canc Ctr, Ctr RNA Biomed, Dept Radiat Oncol, Ann Arbor, MI 48109 USA.
2019 (English)In: Mutation Research, ISSN 1383-5742, E-ISSN 1388-2139, Vol. 780, p. 48-54Article, review/survey (Refereed) Published
Abstract [en]

Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing transcription elongation and by serving as landing sites for proteins involved in the DNA damage response. This review summarizes the current understanding of the role of H3K79 methylation in transcription, how it affects genome stability and opportunities to develop impactful therapeutic interventions for cancer.

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ELSEVIER , 2019. Vol. 780, p. 48-54
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:uu:diva-394152DOI: 10.1016/j.mrrev.2017.11.001ISI: 000482503800006PubMedID: 31395348OAI: oai:DiVA.org:uu-394152DiVA, id: diva2:1357479
Available from: 2019-10-04 Created: 2019-10-04 Last updated: 2019-10-04Bibliographically approved

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