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Adipose lipid turnover and long-term changes in body weight
Karolinska Inst, Karolinska Univ Hosp, Dept Med, Stockholm, Sweden.
Univ Lyon, CNRS, UMR5208, Inst Camille Jordan, Villeurbanne, France.
Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden.
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
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2019 (English)In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 25, no 9, p. 1385-1389Article in journal (Refereed) Published
Abstract [en]

The worldwide obesity epidemic(1) makes it important to understand how lipid turnover (the capacity to store and remove lipids) regulates adipose tissue mass. Cross-sectional studies have shown that excess body fat is associated with decreased adipose lipid removal rates(2,3). Whether lipid turnover is constant over the life span or changes during long-term weight increase or loss is unknown. We determined the turnover of fat cell lipids in adults followed for up to 16 years, by measuring the incorporation of nuclear bomb test-derived C-14 in adipose tissue triglycerides. Lipid removal rate decreases during aging, with a failure to reciprocally adjust the rate of lipid uptake resulting in weight gain. Substantial weight loss is not driven by changes in lipid removal but by the rate of lipid uptake in adipose tissue. Furthermore, individuals with a low baseline lipid removal rate are more likely to remain weight-stable after weight loss. Therefore, lipid turnover adaptation might be important for maintaining pronounced weight loss. Together these findings identify adipose lipid turnover as an important factor for the long-term development of overweight/obesity and weight loss maintenance in humans.

Place, publisher, year, edition, pages
2019. Vol. 25, no 9, p. 1385-1389
National Category
Biophysics Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-394253DOI: 10.1038/s41591-019-0565-5ISI: 000484832800020PubMedID: 31501613OAI: oai:DiVA.org:uu-394253DiVA, id: diva2:1359438
Funder
Swedish Research Council, K2014-54x-14510-12-5Swedish Research Council, K2012-55x-01034-46-5Swedish Research Council, 542-2013-8358Novo Nordisk, NNF120 C1016064Novo Nordisk, NNF15SA0018346Novo Nordisk, NNF15CC0018486Novo Nordisk, 120C101637Swedish Diabetes Association, DIA2016-097Available from: 2019-10-09 Created: 2019-10-09 Last updated: 2019-10-09Bibliographically approved

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