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Bone loss in elderly women prevented by ultralow doses of parenteral 17beta-estradiol.
1997 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 177, no 1, p. 115-9Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Our purpose was to assess whether an ultralow dose of parental estradiol, aimed for treatment of vaginal atrophy, affects bone metabolism and bone density.

STUDY DESIGN: Thirty healthy women > or = 60 years old were randomly assigned to a 6-month treatment with either an ultralow dose of parenteral estradiol (7.5 microg/24 hours) delivered by vaginal rings or no treatment in the proportion 2:1.

RESULTS: Forearm bone density increased in estradiol users by 2.1% (95% confidence interval 0.4 to 3.8, p = 0.008), contrasting to a decrease in nonusers of -2.7% (95% confidence interval -5.9 to 0.4, p = 0.077). In analysis of variance the changes in the two study groups differed significantly (p = 0.0004). Consistently, serum alkaline phosphatases, bone-specific alkaline phosphatases, and osteocalcin concentrations decreased in the treatment group (8%, p = 0.019; 14%, p = 0.0006; and 9%, p = 0.02, respectively), suggesting reduced bone turnover. No significant changes were found in nonusers.

CONCLUSION: Ultralow doses of estradiol may potentially prevent bone loss in women > or = 60 years old.

Place, publisher, year, edition, pages
1997. Vol. 177, no 1, p. 115-9
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-394861DOI: 10.1016/s0002-9378(97)70448-4PubMedID: 9240593OAI: oai:DiVA.org:uu-394861DiVA, id: diva2:1359635
Available from: 2019-10-09 Created: 2019-10-09 Last updated: 2020-02-20Bibliographically approved

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