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Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience
Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN USA.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN USA; Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN USA; Vanderbilt Univ, Sch Med, Program Canc Biol, Nashville, TN USA.
2019 (English)In: ADVANCES IN CHRONIC KIDNEY DISEASE, ISSN 1548-5595, Vol. 26, no 4, p. 253-266Article in journal (Refereed) Published
Abstract [en]

Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production and coordinates erythropoiesis with iron metabolism. Small molecule inhibitors of prolyl hydroxylase domain dioxygenases (HIF-PHI [prolyl hydroxylase inhibitor]) stimulate the production of endogenous erythropoietin and improve iron metabolism resulting in efficacious anemia management in patients with CKD. Three oral HIF-PHIS-daprodustat, roxadustat, and vadadustat-have now advanced to global phase III clinical development culminating in the recent licensing of roxadustat for oral anemia therapy in China. Here, we survey current clinical experience with HIF-PHIs, discuss potential therapeutic advantages, and deliberate over safety concerns regarding long-term administration in patients with renal anemia.

Place, publisher, year, edition, pages
2019. Vol. 26, no 4, p. 253-266
Keywords [en]
Anemia, Chronic kidney disease, Prolyl hydroxylase domain, Hypoxia-inducible factor, Erythropoietin
National Category
Urology and Nephrology Hematology
Identifiers
URN: urn:nbn:se:uu:diva-394980DOI: 10.1053/j.ackd.2019.04.004ISI: 000486735400006PubMedID: 31477256OAI: oai:DiVA.org:uu-394980DiVA, id: diva2:1360212
Available from: 2019-10-11 Created: 2019-10-11 Last updated: 2019-10-11Bibliographically approved

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Haase, Volker H.

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