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Hepatic oxygen consumption and cytochrome P450 activity in experimental faecal peritonitis.
1993 (English)In: European Journal of Surgery, ISSN 1102-4151, E-ISSN 1741-9271, Vol. 159, no 4, p. 201-7Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To study hepatic oxygen consumption and cytochrome P450 activity in pigs with septic shock induced by faecal peritonitis.

DESIGN: Controlled experimental study.

ANIMALS: 12 pigs weighing 19-27 kg.

INTERVENTION: The animals were divided into a control group (n = 6) and a peritonitis group (n = 6). Peritonitis was induced by intraperitoneal instillation of a standard amount of autologous faeces. The animals were then observed for 300 minutes. Liver biopsy specimens were taken at 0 and 300 minutes.

MAIN OUTCOME MEASURES: Hepatic oxygen delivery (DO2) and consumption (VO2). Cytochrome P450 activity was studied by measuring O- and N-demethylation of codeine at 0 and 300 minutes.

RESULTS: Hepatic DO2 was reduced, whereas VO2 was increased during sepsis. There were no significant changes in the N- and O-demethylation of codeine.

CONCLUSIONS: Hepatic VO2 did increase during sepsis, possibly because of the increased metabolic demand. Cytochrome P450 activity was unaffected by the septic challenge.

Place, publisher, year, edition, pages
1993. Vol. 159, no 4, p. 201-7
National Category
Surgery Physiology
Identifiers
URN: urn:nbn:se:uu:diva-395087PubMedID: 8102539OAI: oai:DiVA.org:uu-395087DiVA, id: diva2:1360395
Available from: 2019-10-12 Created: 2019-10-12 Last updated: 2019-10-12

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