uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cell Cycle Regulator p27 Mediates Body Mass IndexEffects in Ovarian Cancer in FIGO-stages I-II
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive biology.ORCID iD: 0000-0001-9840-2240
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. (Helena Åkerud)
Department of Pathology, Halmstad Medical Center Hospital, Halmstad, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health. (Reproduktiv hälsa/Sundström Poromaa)ORCID iD: 0000-0002-2491-2042
2019 (English)In: Cancer Genomics & Proteomics, ISSN 1109-6535, E-ISSN 1790-6245, Vol. 16, no 6, p. 443-450Article in journal (Refereed) Published
Abstract [en]

Background/Aim: The aim of the present study was to evaluate the association between body mass index (BMI), the biomarker p27, and the clinical factors in FIGO-stages I-II ovarian cancer. Patients and Methods: A total of 128 patients with ovarian cancer were included in the study. For testing differences in univariate analyzes we used the Pearson's Chi-square test and the log-rank test. For multivariate analyses the logistic regression and Cox regression models were used with recurrent disease and disease free survival as endpoints, respectively. Results: Patients with BMI <= 25 kg/m(2) had a significantly better 5-year disease free survival compared with patients with BMI >25 kg/m(2) in the total series of patients (p=0.008), and in the series of patients (n=77) with non-serous tumors (p=0.047). Patients with p27-positive non-serous tumors had higher survival compared to patients with p27-negative non-serous tumors (p=0.020). Conclusion: The cell cycle regulator p27 mediates BMI effects in ovarian cancer in FIGO-stages I-II.

Place, publisher, year, edition, pages
International Institute of Anticancer Research, 2019. Vol. 16, no 6, p. 443-450
Keywords [en]
BMI, p27, non-serous tumors, ovarian cancer, FIGOstages I-II.
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-396005DOI: 10.21873/cgp.20148ISI: 000493397500004PubMedID: 31659099OAI: oai:DiVA.org:uu-396005DiVA, id: diva2:1366235
Available from: 2019-10-28 Created: 2019-10-28 Last updated: 2019-11-18Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Skírnisdottir, IngiridurÅkerud, HelenaSundström-Poromaa, Inger

Search in DiVA

By author/editor
Skírnisdottir, IngiridurÅkerud, HelenaSundström-Poromaa, Inger
By organisation
Reproductive biologyMedicinsk genetik och genomikReproductive Health
In the same journal
Cancer Genomics & Proteomics
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 24 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf