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Short- and long-term effect of contraceptive methods on fecundity
NaturalCycles Nord AB, Luntmakargatan 26, S-11137 Stockholm, Sweden.
NaturalCycles Nord AB, Luntmakargatan 26, S-11137 Stockholm, Sweden.
Karolinska Inst, Dept Clin Sci, Danderyd Hosp, Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
NaturalCycles Nord AB, Luntmakargatan 26, S-11137 Stockholm, Sweden.
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2019 (English)In: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 24, no 4, p. 260-265Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of the study was to compare the effect of previously used contraceptive methods on women's short- and long-term fecundity. Use of hormonal contraception (HC) was compared with the use of a contraceptive mobile application (app). Methods: This real-life prospective observational study comprised 2874 women who were attempting to become pregnant using the Natural Cycles mobile app to monitor their fertility. The women registered to use the app between August 2014 and June 2016 with the intention of planning a pregnancy and had previously either used the same app to prevent pregnancy or had recently discontinued HC use. We calculated the average time to pregnancy (TTP) for all women who became pregnant during the study and performed Kaplan-Meier life-table analysis to examine the cumulative probabilities of pregnancy for all women in the study. Results: The average TTP was 2.3 (95% confidence interval [CI] 2.1, 2.4) and 3.7 (95% CI 3.4, 3.9) cycles for women who had previously used Natural Cycles and HC, respectively. The time to reach 30% pregnancy probability for women previously on HC was 1.6 (95% CI 1.5, 1.8) times longer than for women previously using Natural Cycles. There was no significant difference in the 13 cycle cumulated pregnancy probability between the two groups. Conclusion: The results show that fertility awareness-based methods of contraception increase short-term pregnancy rates relative to HC, but have no effect on long-term pregnancy rates.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2019. Vol. 24, no 4, p. 260-265
Keywords [en]
Conception rate, contraceptive, mobile application, subfertility, time to pregnancy
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-396153DOI: 10.1080/13625187.2019.1621999ISI: 000472450700001PubMedID: 31223036OAI: oai:DiVA.org:uu-396153DiVA, id: diva2:1367559
Available from: 2019-11-04 Created: 2019-11-04 Last updated: 2019-11-04Bibliographically approved

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