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Protective effects of Clec11a in islets against lipotoxicity via modulation of proliferation and lipid metabolism in mice
Southeast Univ, Sch Med, Inst Diabet, Dept Endocrinol,Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China;Southeast Univ, Sch Med, Nanjing 210009, Jiangsu, Peoples R China.
Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China.
Southeast Univ, Sch Med, Inst Diabet, Dept Endocrinol,Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China.
Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China.
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2019 (English)In: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 384, no 1, article id 111613Article in journal (Refereed) Published
Abstract [en]

The lipotoxicity is considered as one of the risk for diabetes. Here we report C-type lectin domain family 11, member A (Clec11a) as a new regulator in islet playing a protective role in lipotoxicity induced dysfunction. Islet transcriptome sequencing was performed using the high-fat diet induced obesity (DIO) mice model. We found a significant decrease of Clec11a expression in islets of DIO mice compared to normal control mice, which was further confirmed by real-time PCR. Immunostaining demonstrated the localization of the Clec11a protein in mouse islets. Administration of recombinant human Clec11a (rClec11a) protein promoted the proliferation of islet cells and rescued the inhibition of fatty acid on cell proliferation, which involved the activation of Erk signaling pathway. We also found that the rClec11a altered the expression of genes involved in lipid metabolism.

Place, publisher, year, edition, pages
ELSEVIER INC , 2019. Vol. 384, no 1, article id 111613
Keywords [en]
Clec11a, Beta cell, Islet, Lipotoxicity, Proliferation
National Category
Endocrinology and Diabetes Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-396433DOI: 10.1016/j.yexcr.2019.111613ISI: 000490031700016PubMedID: 31494095OAI: oai:DiVA.org:uu-396433DiVA, id: diva2:1368104
Available from: 2019-11-06 Created: 2019-11-06 Last updated: 2019-11-06Bibliographically approved

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