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Functional outcome and health-related quality of life in patients with sacrococcygeal teratoma - a Swedish multicenter study
Skane Univ Hosp, Dept Pediat Surg, Lund, Sweden;Lund Univ, Inst Clin Res, Lund, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.ORCID iD: 0000-0001-9578-1783
Karolinska Univ Hosp, Dept Pediat Surg, Stockholm, Sweden;Karolinska Inst, Stockholm, Sweden.
Karolinska Univ Hosp, Dept Pediat Surg, Stockholm, Sweden;Karolinska Inst, Stockholm, Sweden.
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2019 (English)In: Journal of Pediatric Surgery, ISSN 0022-3468, E-ISSN 1531-5037, Vol. 54, no 8, p. 1638-1643Article in journal (Refereed) Published
Abstract [en]

Background/Purpose: The aims of this study were to evaluate bowel and urinary tract function, to identify predictors for dysfunctional outcome and to evaluate health-related quality-of life (QoL) in patients treated for sacrococcygeal teratomas (SCT). Methods: Medical records of patients with SCT born between 1985 and 2015 treated at three Swedish pediatric surgical centers were reviewed. Questionnaires regarding urinary tract function, bowel function and QoL were sent to patients and parents. Different QoL instruments were used for the different age groups. Results: Totally 85 patients were identified. Four patients died in the neonatal period. Forty-nine patients answered the questionnaires (60%). Median age at follow-up was 8.9 years (range 3.6-28.8). Bowel dysfunction was reported by 36% and urinary tract dysfunction by 46% of the patients. Univariate analysis revealed that urinary tract dysfunction correlated with gestational age (p = 0.018) and immature histology (p = 0.008), and bowel dysfunction correlated with gestational age (p = 0.016) and tumor size (p = 0.042). Low gestational age was an independent predictor for both urinary tract and bowel dysfunction. Good or very good QoL was reported by 56% of children aged 4-7 years, 90% of children aged 8-17 years and 67% of the adults. Conclusion: Although a considerable proportion of bowel and urinary tract dysfunction was found, the reported QoL was good in a majority of the patients with SCT. Low gestational age was found to be a predictor for bowel-and urinary tract dysfunction. (C) 2018 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
W B SAUNDERS CO-ELSEVIER INC , 2019. Vol. 54, no 8, p. 1638-1643
Keywords [en]
Sacrococcygeal teratoma, Outcome, Quality of life
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-393744DOI: 10.1016/j.jpedsurg.2018.10.044ISI: 000481622100022PubMedID: 30420172OAI: oai:DiVA.org:uu-393744DiVA, id: diva2:1369173
Available from: 2019-11-11 Created: 2019-11-11 Last updated: 2019-11-11Bibliographically approved

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Al-Mashhadi, AmmarEngstrand Lilja, Helene

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