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Associations of dietary polychlorinated biphenyls and long-chain omega-3 fatty acids with stroke risk.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.ORCID iD: 0000-0003-0118-0341
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2016 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 94, p. 706-711, article id S0160-4120(16)30270-7Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Little is known about joint exposure to polychlorinated biphenyls (PCBs) and long-chain omega-3 fatty acids [eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)], through fish consumption, on cerebrovascular disease risk.

OBJECTIVE: To explore associations of dietary PCB exposure and EPA-DHA intake with risk of different stroke subtypes.

METHODS: This was assessed in the prospective population-based Cohort of Swedish Men including 39,948, middle-aged and elderly men, who were free of cardiovascular disease and cancer at baseline in 1997. Validated estimates of dietary PCBs and EPA-DHA were obtained via a food frequency questionnaire.

RESULTS: During 12years of follow-up, 2286 and 474 incident cases of ischemic stroke and hemorrhagic stroke, respectively, were ascertained through register linkage. Dietary PCB exposure and EPA-DHA intake were associated with hemorrhagic stroke but not ischemic stroke. Men in the highest quartile of dietary PCB exposure (median 412ng/day) had a multivariable- and EPA-DHA-adjusted RR of hemorrhagic stroke of 2.77 [95% confidence interval (CI), 1.48-5.19] compared with men in the lowest quartile (median 128ng/day; p for trend <0.01). The corresponding RRs in men with and without hypertension were 5.45 (95% CI, 1.34-22.1) and 2.37 (95% CI 1.17-4.79), respectively. The multivariable- and PCB-adjusted RR of hemorrhagic stroke for the highest quartile of EPA-DHA intake (median 0.73g/day) versus the lowest quartile (median 0.18g/day) was 0.42 (95% CI, 0.22-0.79).

CONCLUSION: Dietary PCB exposure was associated with an increased risk of hemorrhagic stroke, whereas a protective association was observed for dietary EPA-DHA intake.

Place, publisher, year, edition, pages
2016. Vol. 94, p. 706-711, article id S0160-4120(16)30270-7
Keywords [en]
Hemorrhagic stroke, Ischemic stroke, Long-chain omega-3 fatty acids, Polychlorinated biphenyls
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Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:uu:diva-397336DOI: 10.1016/j.envint.2016.07.012PubMedID: 27473885OAI: oai:DiVA.org:uu-397336DiVA, id: diva2:1371272
Available from: 2019-11-19 Created: 2019-11-19 Last updated: 2020-01-17Bibliographically approved

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Larsson, Susanna C.Wolk, Alicja

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