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Combined impact of healthy lifestyle factors on risk of atrial fibrillation: Prospective study in men and women.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.ORCID iD: 0000-0003-0118-0341
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.ORCID iD: 0000-0001-7387-6845
2016 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 203, p. 46-9, article id S0167-5273(15)30664-1Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The combined impact of multiple lifestyle factors on risk of atrial fibrillation (AF) remains unclear. We investigated the joint association of four modifiable lifestyle factors on incidence of AF in a prospective study of men and women.

METHODS: The study cohort comprised 39 300 men in the Cohort of Swedish Men and 33 090 women in the Swedish Mammography Cohort who were 45-83 years of age and free from atrial fibrillation at baseline. Healthy lifestyle was defined as body mass index <25 kg/m(2), regular exercise for ≥ 20 min/day, no or light-to-moderate alcohol consumption (≤ 2 drinks/day for men and ≤ 1 drink/day for women), and not smoking. Incident AF cases were identified through linkage with the Swedish National Inpatient Register.

RESULTS: During a mean follow-up of 10.9 years, AF occurred in 4028 men and 2539 women. Compared with men and women with no healthy lifestyle factors, the multivariable relative risks (95% confidence interval) of AF were 0.83 (0.65-1.07) for one, 0.74 (0.58-0.94) for two, 0.62 (0.49-0.79) for three, and 0.50 (0.39-0.64) for four healthy lifestyle factors (P for trend <0.0001). The inverse association was similar in men and women.

CONCLUSIONS: Four healthy lifestyle factors combined were associated with a halving of the risk of AF.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 203, p. 46-9, article id S0167-5273(15)30664-1
Keywords [en]
Alcohol, Atrial fibrillation, Body mass index, Lifestyle, Physical activity, Smoking
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-397351DOI: 10.1016/j.ijcard.2015.10.106PubMedID: 26512817OAI: oai:DiVA.org:uu-397351DiVA, id: diva2:1371285
Available from: 2019-11-19 Created: 2019-11-19 Last updated: 2020-01-17Bibliographically approved

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Larsson, Susanna C.Wolk, Alicja

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