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R3hdml regulates satellite cell proliferation and differentiation
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan.
Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan.
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan.
Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan.
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2019 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 20, no 11, article id e47957Article in journal (Refereed) Published
Abstract [en]

In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to control mice. Expression levels of cell cycle-related markers, phosphorylation of Akt, and expression of insulin-like growth factor within the skeletal muscle are reduced in R3hdml KO mice compared to control mice. Expression of R3hdml increases during muscle regeneration in response to cardiotoxin (CTX)-induced muscle injury. Recovery of handgrip strength after CTX injection was significantly impaired in R3hdml KO mice, which is rescued by R3hdml. Our results indicate that R3hdml is required for skeletal muscle development, regeneration, and, in particular, satellite cell proliferation and differentiation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 20, no 11, article id e47957
Keywords [en]
R3hdml, sarcopenia, satellite cell, skeletal muscle
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-398030DOI: 10.15252/embr.201947957ISI: 000496229500004PubMedID: 31524320OAI: oai:DiVA.org:uu-398030DiVA, id: diva2:1375077
Available from: 2019-12-04 Created: 2019-12-04 Last updated: 2020-01-13Bibliographically approved

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Betsholtz, Christer

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