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Emerging links between cerebrovascular and neurodegenerative diseases-a special role for pericytes
Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden;Karolinska Inst, Ctr Alzheimer Res, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, Solna, Sweden;ICMC, Huddinge, Sweden.
Karolinska Inst, Ctr Alzheimer Res, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, Solna, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. ICMC, Huddinge, Sweden;Karolinska Inst, Dept Med, Huddinge, Sweden.ORCID iD: 0000-0002-8494-971x
2019 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 20, no 11, article id e48070Article, review/survey (Refereed) Published
Abstract [en]

Neurodegenerative and cerebrovascular diseases cause considerable human suffering, and therapy options for these two disease categories are limited or non-existing. It is an emerging notion that neurodegenerative and cerebrovascular diseases are linked in several ways, and in this review, we discuss the current status regarding vascular dysregulation in neurodegenerative disease, and conversely, how cerebrovascular diseases are associated with central nervous system (CNS) degeneration and dysfunction. The emerging links between neurodegenerative and cerebrovascular diseases are reviewed with a particular focus on pericytes-important cells that ensheath the endothelium in the microvasculature and which are pivotal for blood-brain barrier function and cerebral blood flow. Finally, we address how novel molecular and cellular insights into pericytes and other vascular cell types may open new avenues for diagnosis and therapy development for these important diseases.

Place, publisher, year, edition, pages
2019. Vol. 20, no 11, article id e48070
Keywords [en]
blood-brain barrier, cerebrovascular disease, neurodegenerative disease, neurovascular unit, pericyte
National Category
Neurosciences Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-398132DOI: 10.15252/embr.201948070ISI: 000496229500013PubMedID: 31617312OAI: oai:DiVA.org:uu-398132DiVA, id: diva2:1375145
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationSwedish Cancer SocietyAvailable from: 2019-12-04 Created: 2019-12-04 Last updated: 2019-12-04Bibliographically approved

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Betsholtz, Christer

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