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The effect of Edaravone on Amyloid beta aggregation
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2019 (English)Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abstract [en]

Alzheimer’s disease (AD) is a devastating neurodegenerative disease that affect millions of people worldwide. Aggregation of Amyloid-β (Aβ) monomers create toxic oligomers that can interact with cellular membranes and disturb cellular functions, resulting in cell death and neurological dysfunction. Increased levels of oxidative stress have been shown in the brains of AD patients, something that besides the obvious cell and tissue toxicity, also favors the amyloidogenic pathway and generates more Aβ monomers. Here we show that Edaravone, a free radical scavenger can affect the aggregation rate of different lengths of Aβ. We show that Aβ-40 that is more commonly found in vivo aggregates faster with addition of Edaravone, while Aβ-42 aggregates slower or not at all. These findings add up to previous findings where free radical scavengers and antioxidants such as Edaravone have been suggested as a potential treatment in Alzheimer’s disease.

Place, publisher, year, edition, pages
2019.
Keywords [en]
Edaravone, Amyloid beta
National Category
Biophysics Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-398469OAI: oai:DiVA.org:uu-398469DiVA, id: diva2:1375900
Educational program
Master Programme in Biology
Available from: 2019-12-13 Created: 2019-12-06 Last updated: 2019-12-13Bibliographically approved

Open Access in DiVA

The full text will be freely available from 2020-06-01 12:00
Available from 2020-06-01 12:00

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