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The prediction of colorectal cancer using anthropometric measures: A Swedish population-based cohort study with 22 years of follow-up
Karolinska Inst, Dept Med, Unit Clin Med, Stockholm, Sweden;Stockholm Univ, Stress Res Inst, Stockholm, Sweden;Macquarie Univ, Dept Psychol, N Ryde, NSW, Australia.
Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden;Karolinska Univ Hosp, Dept Upper GI, Unit Hepatol, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Colorectal Surgery. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Upper Abdominal Surgery.ORCID iD: 0000-0002-1176-5143
Skane Univ Hosp, Dept Gastroenterol & Hepatol, Malmo, Sweden.
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2019 (English)In: United European Gastroenterology journal, ISSN 2050-6406, E-ISSN 2050-6414, Vol. 7, no 9, p. 1250-1260Article in journal (Refereed) Published
Abstract [en]

Background Obesity is a risk factor for colorectal cancer (CRC). Objective The objective of this article is to investigate whether anthropometric measures reflecting visceral obesity are better predictors of CRC than body mass index (BMI). Methods Data were analysed from the Malmo Diet and Cancer study in Sweden, comprising 16,669 women and 10,805 men (median age 56.6 and 59.1 years) followed for a median 21.5 years. Diagnoses of CRC were identified using Swedish national registers. Cox regression was used to test the associations of BMI, waist circumference (WC), waist-hip ratio, waist-to-height ratio, waist-to-hip-to-height ratio, A Body Shape Index (ABSI) and percentage body fat with the development of CRC adjusted for age, alcohol consumption, smoking, education and physical activity in men and women. Results None of the measures were significantly associated with an increased risk for CRC in women. WC was the strongest predictor of colon cancer (CC) in men and the only measure that was independent of BMI. ABSI was the only measure significantly associated with the risk of rectal cancer in men. Conclusions Visceral obesity, best expressed as WC, is a risk factor for CC in men but a poor predictive marker for CRC in women.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS INC , 2019. Vol. 7, no 9, p. 1250-1260
Keywords [en]
Anthropometric measures, A Body Shape Index, body mass index, colon cancer, colorectal cancer, colorectal cancer risk, predictive value, rectal cancer, waist circumference, waist-to-height-ratio
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Gastroenterology and Hepatology
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URN: urn:nbn:se:uu:diva-397302DOI: 10.1177/2050640619854278ISI: 000492595300012PubMedID: 31700638OAI: oai:DiVA.org:uu-397302DiVA, id: diva2:1375922
Available from: 2019-12-06 Created: 2019-12-06 Last updated: 2019-12-06Bibliographically approved

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