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Radiation-Induced Meningiomas After Childhood Brain Tumor: A Magnetic Resonance Imaging Screening Study
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland.ORCID iD: 0000-0003-4318-5343
Univ Oulu, POB 28, Oulu 90029, Finland;Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland;Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.
Oulu Univ Hosp, Dept Oncol & Radiotherapy, Oulu, Finland.
Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.
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2019 (English)In: Journal of Adolescent and Young Adult Oncology, ISSN 2156-5333, Vol. 8, no 5, p. 593-601Article in journal (Refereed) Published
Abstract [en]

Purpose: Childhood brain tumors (CBTs) and their treatment increase the risk of secondary neoplasms (SNs). We studied the incidence of secondary craniospinal tumors with magnetic resonance imaging (MRI) screening in a national cohort of survivors of CBT treated with radiotherapy, and we analyzed the Finnish Cancer Registry (FCR) data on SNs in survivors of CBT with radiotherapy registered as a part of the primary tumor treatment. Methods: A total of 73 survivors of CBT participated in the MRI study (mean follow-up of 19 +/- 6.2 years). The incidence of SNs in a cohort of CBT patients (N = 569) was retrieved from the FCR (mean follow-up of 11 +/- 12.9 years). Brain tumors were diagnosed at age <= 16 years between the years 1970 and 2008 in the clinical study and the years 1963 and 2010 in the FCR population. Results: Secondary brain tumors, meningiomas in all and schwannoma in one, were found in 6 of the 73 (8.2%) survivors with a mean of 23 +/- 4.3 years after the diagnosis of the primary tumor. The cumulative incidence was 10.2% (95% confidence interval [CI] 3.9-25.1) in 25 years of follow-up. In the FCR data, the 25-year cumulative incidence of SNs was 2.4% (95% CI 1.3-4.1); only two brain tumors, no meningiomas, were registered. Conclusion: Survivors of CBT treated with radiotherapy have a high incidence of meningiomas, which are rarely registered in the FCR.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2019. Vol. 8, no 5, p. 593-601
Keywords [en]
secondary neoplasms, meningiomas, children, brain tumors, irradiation, survivors
National Category
Radiology, Nuclear Medicine and Medical Imaging Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-398725DOI: 10.1089/jayao.2019.0010ISI: 000470810100001PubMedID: 31063432OAI: oai:DiVA.org:uu-398725DiVA, id: diva2:1376967
Available from: 2019-12-10 Created: 2019-12-10 Last updated: 2019-12-10Bibliographically approved

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Harila-Saari, Arja H.

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