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Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear
Hiroshima Univ Hosp, Dept Otolaryngol, Hiroshima, Japan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2019 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 139, no 11, p. 948-952Article in journal (Refereed) Published
Abstract [en]

Background: In the inner ear, evidence has been gathered indicating that melatonin plays important roles in inner ear physiology and pathophysiology. However, no attempt has been made previously to investigate the localization or expression of melatonin and its receptors in the whole inner ear. Aims/objectives: To analyze the presence of melatonin and its receptors in the normal mouse inner ear. Material and methods: C57BL6/J mice were used in this study. The localizations of melatonin, MT1a and MT1b in the inner ear, i.e. cochlea, vestibular end organs, vestibular ganglion and endolymphatic sac (ES), were studied by immunohistochemistry. Results: The organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory cells, vestibular dark and transitional cells, and ES epithelial cells showed an immunofluorescence reaction to melatonin, MT1a and MT1b.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2019. Vol. 139, no 11, p. 948-952
Keywords [en]
Melatonin, melatonin receptor, inner ear, mouse, immunohistochemistry
National Category
Otorhinolaryngology Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-398857DOI: 10.1080/00016489.2019.1655587ISI: 000485823200001PubMedID: 31561736OAI: oai:DiVA.org:uu-398857DiVA, id: diva2:1377316
Available from: 2019-12-11 Created: 2019-12-11 Last updated: 2019-12-11Bibliographically approved

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Anniko, Matti

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