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Hypertension and cardiovascular diseases in Swedish persons with haemophilia - A longitudinal registry study
Lund Univ, Dept Translat Med, Clin Coagulat Res Unit, Malmo, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. AstraZeneca, Dept Epidemiol, R&D, Molndal, Sweden.
Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Med Hematol & Coagulat Disorders, Coagulat Ctr, Gothenburg, Sweden.
Karolinska Inst, Karolinska Univ Hosp, Dept Med, Coagulat Unit, Stockholm, Sweden.
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2019 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 181, p. 106-111Article in journal (Refereed) Published
Abstract [en]

Introduction: Data on the prevalence of hypertension and cardiovascular diseases (CVD) among persons with haemophilia (PWH) vary. Sweden has a long tradition of maintaining population-based data registries, and there is extensive follow-up of haemophilia patients due to the use of prophylaxis over decades. We evaluated the prevalence of these diseases among Swedish PWH compared to matched controls using a longitudinal study design.

Methods: Data were obtained from the National Patient Registry and linked to records of persons with haemophilia enrolled in the haemophilia centres. For each subject, five gender and age matched controls were identified.

Results: We identified 193 (19.7%) diagnoses of hypertension in PWH born in 1978 or earlier over >= 30 years compared with 550 (11.2%) among controls. The median ages and interquartile ranges were 60.0 (42.8, 69.9) and 57.2 (42.6, 70.6) years. The hazard rate (HR) for hypertension, PWH vs. controls, was 2.1, 95% CI: [1.8; 2.5], p < 0.001. The findings were similar in subgroup analyses of patients with non-severe and severe haemophilia with or without HIV and/or viral hepatitis. Angina pectoris was diagnosed in 69 (4.8%) of patients censored at age 75 compared with 311 (4.3%) in controls, and myocardial ischemia in 84 (5.9%) compared with 442 (6.2%). As a cause of death, the HR for myocardial ischemia, comparing PWH and controls, was 0.58, 95% CI: [0.42, 0.80], p = 0.001.

Conclusion: Our data support an increased prevalence of hypertension among persons with haemophilia. The prevalence of CVD seems to be similar to that of controls, but with lower mortality.

Place, publisher, year, edition, pages
2019. Vol. 181, p. 106-111
Keywords [en]
Haemophilia, Hypertension, Cardiovascular disease, HIV, Hepatitis
National Category
Hematology Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-399024DOI: 10.1016/j.thromres.2019.07.017ISI: 000481624200017PubMedID: 31386935OAI: oai:DiVA.org:uu-399024DiVA, id: diva2:1378519
Available from: 2019-12-13 Created: 2019-12-13 Last updated: 2019-12-13Bibliographically approved

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Henriksson, Karin M.

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