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VEGF Receptor Tyrosine Kinases: Key Regulators of Vascular Function
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.ORCID iD: 0000-0003-0770-4214
Karolinska Inst, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.ORCID iD: 0000-0002-2682-2833
2017 (English)In: Protein Kinases In Development And Disease / [ed] Jenny, A, Elsevier, 2017, p. 433-482Chapter in book (Refereed)
Abstract [en]

Vascular endothelial growth factor receptor (VEGFR) tyrosine kinases are key regulators of vascular development in vertebrates. Their activation is regulated through a family of secreted glycoproteins, the vascular endothelial growth factors (VEGFs). Expression, proteolytic processing, and diffusion range of VEGF proteins need to be tightly regulated, due to their crucial roles in development. While some VEGFs form concentration gradients across developing tissues and act as morphogenes, others function as inhibitors of receptor activation and downstream signaling. Ligand-induced receptor dimerization leads to activation of the intrinsic tyrosine kinase activity, which results in autophosphorylation of the receptors and in turn triggers the recruitment of interacting proteins as well as the initiation of downstream signaling. Although many biochemical details of VEGFR signaling have been revealed, the in vivo relevance of certain signaling aspects still remains to be demonstrated. Here, we highlight basic principles of VEGFR signaling and discuss its crucial role during development of the vascular system in mammals.

Place, publisher, year, edition, pages
Elsevier, 2017. p. 433-482
Series
Current Topics in Developmental Biology, ISSN 0070-2153 ; 123
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-399796DOI: 10.1016/bs.ctdb.2016.10.001ISI: 000468585500014PubMedID: 28236974ISBN: 978-0-12-801513-1 (print)OAI: oai:DiVA.org:uu-399796DiVA, id: diva2:1379409
Available from: 2019-12-17 Created: 2019-12-17 Last updated: 2019-12-17Bibliographically approved

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