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The human secretome
KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden;Tech Univ Denmark, Ctr Biosustainabil, Lyngby, Denmark;Karolinska Inst, Dept Neurosci, Stockholm, Sweden.ORCID iD: 0000-0002-4858-8056
KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden.
KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden.ORCID iD: 0000-0001-8947-2562
KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden.
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2019 (English)In: Science Signaling, ISSN 1945-0877, E-ISSN 1937-9145, Vol. 12, no 609, article id eaaz0274Article in journal (Refereed) Published
Abstract [en]

The proteins secreted by human cells (collectively referred to as the secretome) are important not only for the basic understanding of human biology but also for the identification of potential targets for future diagnostics and therapies. Here, we present a comprehensive analysis of proteins predicted to be secreted in human cells, which provides information about their final localization in the human body, including the proteins actively secreted to peripheral blood. The analysis suggests that a large number of the proteins of the secretome are not secreted out of the cell, but instead are retained intracellularly, whereas another large group of proteins were identified that are predicted to be retained locally at the tissue of expression and not secreted into the blood. Proteins detected in the human blood by mass spectrometry-based proteomics and antibody-based immuno-assays are also presented with estimates of their concentrations in the blood. The results are presented in an updated version 19 of the Human Protein Atlas in which each gene encoding a secretome protein is annotated to provide an open-access knowledge resource of the human secretome, including body-wide expression data, spatial localization data down to the single-cell and subcellular levels, and data about the presence of proteins that are detectable in the blood.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2019. Vol. 12, no 609, article id eaaz0274
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:uu:diva-400051DOI: 10.1126/scisignal.aaz0274ISI: 000499099300003PubMedID: 31772123OAI: oai:DiVA.org:uu-400051DiVA, id: diva2:1380088
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Knut and Alice Wallenberg FoundationAvailable from: 2019-12-18 Created: 2019-12-18 Last updated: 2019-12-18Bibliographically approved

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Lindskog, CeciliaPontén, FredrikKatona, BorbalaVuu, JimmyLindström, Emil

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Uhlen, MathiasHober, AndreasKotol, DavidTebani, AbdellahHaussler, Ragna S.Lindskog, CeciliaPontén, FredrikKatona, BorbalaVuu, JimmyLindström, Emil
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Clinical and experimental pathologyDepartment of Immunology, Genetics and Pathology
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